/News/Research — “Our Hydration Multiplier and Hydration Multiplier Sugar-Free formulas help the body retain fluids for up to four hours—significantly longer than water alone,” said Sai Chaluvadi, vice president of research & development, scientific affairs at Liquid I.V., and also an author on the study.
“They also improve net fluid balance while reducing urine output, translating to longer-lasting hydration and sustained performance. It’s a powerful validation of our goal to always lead with science in a category that impacts people’s lives every day.”
The research was recently presented at the American College of Sports Medicine and American Society for Nutrition annual meetings and then published in Current Developments in Nutrition.
Study details
The study, sponsored by Liquid I.V., was in conducted collaboration with Professor Rick Bloomer, PhD, from the Center for Nutraceutical and Dietary Supplement Research at the University of Memphis.
The study evaluated the hydration effects of consuming 1L of the following four beverages: Water (W), sugar sweetened ORS (ORS, Liquid IV Hydration Multiplier), allulose-sweetened ORS (SF-ORS, Liquid IV Sugar-Free Hydration Multiplier) or non-commercial allulose-sweetened ORS (SF-ORS*).
Allulose is a naturally occurring, rare digestible, but not metabolized sugar with a structure similar to fructose that may have the potential to help with hydration, according to the study authors.
The randomized, single-blind, cross-over study included 28 healthy, euhydrated (normal to optimal level of hydration) subjects between the ages of 20 and 45 to determine the Beverage Hydration Index (BHI), the gold standard method for measuring hydration status, as well as additional variables related to hydration status following the intake of three ORS or water.
The participants reported to the lab weekly for four weeks. During each visit, urine was collected post-intake, with cumulative urine mass measured and fluid balance and BHI calculated.
Findings: Extended hydration, improved fluid retention, extended fluid availability
After four hours, BHI measures for people drinking Liquid I.V. (p=0.028), HM SF (p=0.02) and a non-commercially available allulose-sweetened beverage (p=0.001) were significantly higher compared to water.
Improved fluid retention along with extended fluid availability was also observed. In the study, people who drank water had significantly more urine output compared to those who used ORS (p=0.004), SF-ORS (p<0.0001), and a non-commercially allulose-sweetened beverage (p<0.0001).
All oral hydrating solutions performed better than water for net fluid balance, with a statistically significant difference after four hours for ORS (p=0.004), SF-ORS (p<0.0001) and a non-commercially available allulose-sweetened beverage (p<0.0001).
Liquid I.V.’s Chaluvadi stated that the findings highlight the formula’s physiological advantages, making it especially relevant for clinical hydration, athletic performance, travel recovery and everyday wellness.
“It’s an exciting confirmation of the impact our products can have across so many real-world scenarios,” he said.
Those real-world scenarios are crucial, with Chaluvadi noting that Liquid I.V. will continue to conduct more research on the everyday consumer: “Numerous questions remain unanswered in the field of hydration science, as most research has concentrated on elite athletes. As consumer needs evolve, Liquid I.V. remains dedicated to addressing these challenges through science-driven innovation.”
Research: More to come
In July, Liquid I.V. is slated to present new clinical data on Hydration Multiplier Energy, showing the hydration impact of different caffeine and electrolyte levels compared to water alone.
“To ensure that we are always staying on the cutting edge of hydration science and demonstrating the power of our products across a wide variety of usages, we continue to clinically test all our products,” he said. “Currently, we have finished, are in progress of or have planned over 15 clinical trials across our Hydration Multiplier, Hydration Multiplier Sugar-Free, Hydration Multiplier Energy and new innovations.”
Looking further down the road, Chaluvadi said the logical step in research is to examine the daily advantages of maintaining optimal hydration, termed “hydration for health.”
Source: Current Developments in Nutrition doi:10.1016/j.cdnut.2025.106656. “Oral Rehydration Solutions Improve Measures of Hydration Over a 4hr Period in Healthy Men and Women”. Authors: M. Lelko, et al.
