The joint health market
In the next five years, the global market for bone and joint health ingredients is forecast to grow at a rate of 6.3% (CAGR), mainly due to the graying populations of the developed world. It is projected to reach $3.5 billion U.S. dollars by 20241. While older people are the primary drivers of the joint health market, athletes and weekend warriors are feeling the short-term effects of vigorous exercise on their joints. They are also looking for proactive solutions to help prevent deterioration later in life.
Popular solutions and their limitations
There are various remedies for joint pain and stiffness, but they all have their limitations. Pharmaceuticals, such as nonsteroidal anti-inflammatory drugs (NSAIDs), often have dangerous side effects when used long term. Collagen requires doses high enough to be cumbersome, the scientific evidence for glucosamine is mixed, and there are sustainability problems with the harvesting of Boswellia.
Turmeric is a leading botanical ingredient for joint health. The most popular and researched component of turmeric is curcumin. Although curcumin is well studied for its bioactivity, formulators face significant challenges due to its extremely low bioavailability. Curcumin is not soluble in the aqueous environment of the gastrointestinal tract, due to its polarity and reduced dissolution rate. As a result, it is poorly absorbed in the system. In addition to the bioavailability issue, curcumin is typically extracted with harsh industrial solvents, a concern for many consumers in the age of clean-label products.
Consumers are looking for safe, natural, effective, and convenient solutions for joint health. Is the answer a different kind of turmeric extract?
Water soluble and Oil-soluble components of turmeric
Classic Ayurvedic preparations of turmeric are sometimes oil-based (for example Sneha, which combines turmeric with ghee) and sometimes aqueous (for example Kashaya, which blends turmeric with water).
This shows that both oil and water-soluble portions of turmeric have a history of traditional use.
Yet to date, most of the research on turmeric-based products has been conducted on:
1) Whole turmeric powder
2) Volatile oil portions of turmeric or
3) Isolated curcuminoid extracts (especially curcumin).
Meanwhile, over 90% of the remaining water-soluble constituents of turmeric have been neglected and rarely investigated for their own health benefits. That begs the question: what have we been throwing away?
At Natural Remedies, we were on a quest to discover these unexplored components of turmeric.
After years and years of research by our team of herbalists and scientists, we discovered that turmeric also contains a special class of water-soluble polysaccharides that are potent, promising, and bioactive called Turmerosaccharides.
Discover the Power of Turmerosaccharides
Research indicates that like curcumin and turmerones (another fat-soluble class of turmeric constituents), Turmerosaccharides support joint health and function by easing pain and reducing inflammation. In fact, one in vivo study found an oil-free aqueous extract of turmeric was comparable to curcuminoids and turmerones in combating acute and chronic inflammation. In addition, four well-controlled human clinical trials have found that Turmerosaccharides reduce joint tenderness and support physical function of the joints.
Introducing Turmacin® for pain, inflammation and joint health
Based on positive results from the pre-clinical studies, Natural Remedies developed a unique turmeric extract called Turmacin®, which was then subjected to clinical testing. An innovative ingredient in the crowded turmeric field, Turmacin® is the first standardized turmeric product to focus on the much-ignored water-soluble components of turmeric — Turmerosaccharides.
The Science on Turmacin®
The efficacy for joint health is substantiated by five clinical studies and seven preclinical studies. Studies have shown that it reduces joint pain, and it works quickly (within three hours) with long-lasting (continuing for 24 hours) effects.
Based on the clinical studies, the following health claims are possible; it helps maintain healthy joint function, supports joint mobility, helps to reduce exercise-induced pain, improves joint comfort/mobility during exercise or exertion, and delays the onset of joint discomfort during exercise or exertion.
It exerts its activity through multiple modes of action. It reduces markers of collagen degradation (IL-6, IL-8, COX-2, PGE2, TNF-alpha, ICAM-1) in human articular cartilage cells. It also lowers cartilage damage by increasing gene expression of type II collagen, decreasing gene expression of MMP-3 and MMP-7, and by protecting glycosaminoglycans. It is also known to inhibit NF-kappa-beta, a protein complex implicated in chronic inflammation, and slows hydrogen peroxide-induced aging of cartilage cells. These combined actions slow the degradation of existing cartilage while supporting the synthesis of new cartilage, helping to keep these natural processes in a healthy balance.
Application in Beverages
Turmacin® has achieved self-affirmed GRAS status, so it is approved for use in functional foods and beverages. Unlike fat-soluble curcuminoid preparations, Turmacin® dissolves easily in water and stays in solution. Because it does not precipitate out, it prevents cake formation. Additionally, because it does not contain the highly pigmented curcuminoids, Turmacin® is non-staining of manufacturing equipment, making it easy to work with.
Turmacin® has a battery of certifications, including BSCG drug-free certified, Clean Label Project certified, Non-GMO Project verified and available with USDA and EU organic certification.
As the world population ages, demand for joint health and healthy aging products will only continue to grow. Out of the many possible botanical ingredients, turmeric stands out as a promising solution. Turmacin® is a clinically tested, aqueous based turmeric extract rich in Turmerosaccharides with anti-inflammatory and pain-reducing properties, proving there’s more to turmeric than curcuminoids.
1. Global bone and joint health ingredients market—growth, trends, and forecast (2019-2024). Mordor Intelligence.