Following other animal and human studies that highlighted a beneficial link between coffee and diabetes, the Kao Corporation scientists hypothesised that the glucagon-like peptide 1 (GLP-1) was pivotal in the biological process.
“The present results suggest that polyphenols from coffee may serve as an exogenous physiological regulator of the secretion of incretin with an influence on blood glucose homeostasis,” the researchers concluded.
“This may be important for the further development of GLP-1-based therapies for the treatment of diabetes.”
In the mouse study they found that a coffee polyphenol extract (CPE) induced GLP-1 secretion and decreased postprandial hyperglycaemia, which led them to suggest the ingestion of CPE may improve insulin sensitivity and therefore reduce the likelihood of diabetes 2 setting in.
Journal of Nutritional Science
Volume 4 / 2015 (DOI: http://dx.doi.org/10.1017/jns.2014.71)
‘Ingestion of coffee polyphenols increases postprandial release of the active glucagon-like peptide-1 (GLP-1(7–36)) amide in C57BL/6J mice’
Authors: Yoshie Fujii, Noriko Osaki, Tadashi Hase and Akira Shimotoyodome